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Why diphtheria is making a comeback

JANUARY 23, 20247:30 AM ET from NPR.org https://www.npr.org/sections/goatsandsoda/2024/01/23/1226155791/why-diphtheria-is-making-a-comeback

By Simar Bajaj

The potentially fatal disease diphtheria is caused by bacteria — the club-shaped, Gram-positive, Corynebacterium diphtheriae bacilli shown in this microscope photo.

CDC via AP

It had been over 30 years since the last case of diphtheria was seen in Guinea. So when patients began showing up six months ago with what looked like flu symptoms — fever, cough and sore throat – doctors weren’t alarmed. Until the children started dying.

That’s when they realized that this longtime scourge, long quashed by vaccination, was back.

As of December 2023, there have been around 25,000 cases of diphtheria in West Africa and 800 deaths. In Guinea, the cases were clustered in Siguiri, a rural prefecture in the country’s northeast, and early data showed that 90% occurred in children under the age of 5.

What diphtheria does — and why it’s showing up

Diphtheria is a highly contagious bacterial infection spread through direct contact with infected sores or ulcers but primarily through breathing in respiratory droplets. The bacteria then releases toxins, causing inflammation that blocks the airways; a thick mucus-like substance (called a “pseudomembrane”) can form at the back of the throat.

“This can kill by suffocating the patient,” says Adélard Shyaka, medical coordinator for Doctors Without Borders in Guinea. “But also the toxin moves through the body and can damage the heart, the kidneys, the nervous system.” Such damage — via suffocation, myocarditis, kidney failure and nerve malfunctioning — means diphtheria is fatal in up to 50% of cases without treatment.

The disease, which was a global scourge for much of the 20th century, is also almost entirely preventable through vaccination. After the diphtheria inoculation was included on the World Health Organization’s essential vaccine list in the 1970s, cases decreased dramatically worldwide. “Now, it’s an almost forgotten disease,” says Shyaka.

But that doesn’t mean this outbreak is surprising, according to Ankur Mutreja, a global health specialist with the Cambridge Institute of Therapeutic Immunology and Infectious Disease. “Diphtheria is and has always been a disease of poverty,” he emphasizes, with social unrest and poor vaccination coverage explaining most outbreaks nowadays. “It’s not just the West Africa outbreak but numerous other [recent] outbreaks — after the earthquake in Haiti, after war in Syria, in Bangladesh when the Rohingyas were displaced in 2017,” Mutreja says.

Guinea was particularly vulnerable because of its low diphtheria vaccination rate – only 47% in 2022, with the hardest-hit Siguiri prefecture having even lower coverage at 36%. COVID-19 disrupted routine vaccination campaigns in West Africa and was associated with an uptick in vaccine mistrust, Mutreja says. But for diphtheria and other preventable childhood illnesses, the immunization problem predated the pandemic due to supply chain difficulties, insufficient funding, and complacency, among other reasons, leaving the region vulnerable to a cluster of cases swelling into an outbreak.

Progress and setbacks

In Guinea, Doctors Without Borders says its staff has supported local health workers in addressing diphtheria. Together, they’ve reduced mortality at Siguiri’s Center for the Treatment of Epidemics from 38% to 5% over the past few months. Patients with mild symptoms are sent home with antibiotics, while more severe cases are admitted to the hospital and treated with an antitoxin, as appropriate.

However, shortages of both vaccines and antitoxins continue to hamper a full-scale response to the diphtheria outbreak, according to Louise Ivers, an infectious disease physician and the director of the Harvard Global Health Institute. Presently, only two or three companies make the antitoxin, and each batch of 1,500 doses takes about four weeks to prepare, harvested from horse blood. “Nobody wants to make it,” says Ivers, because of how rarely this antitoxin is usually needed – there were fewer than 9,000 cases globally in 2021 – and how impoverished communities facing diphtheria tend to be. “That puts it into the category of low likelihood of commercial profit.”

The only sure way this outbreak ends is through vaccination, suggests Ivers, who has firsthand experience responding to diphtheria in Haiti between 2003 and 2012. However, similar market dynamics may help explain the global shortage of diphtheria vaccines. “If we can catch back up with DPT [vaccines] and diphtheria boosters and get our communities highly vaccinated,” she says, “then we can prevent outbreaks.”

But the scarcity of vaccines means they’ve only been available for patients and their close contacts in Siguiri. As diphtheria continues to spread in Guinea, Mutreja worries about growing antibiotic resistance and the spread of new variants, which could render existing antitoxins and vaccines ineffective. In fact, resistance has already been increasing, decade over decade, for the past 122 years, as Mutreja described in a 2021 study in Nature Communications. “We mustn’t take our eye off the ball with diphtheria. Otherwise, we risk it becoming a major global threat again, potentially in a modified, better-adapted form,” he says.

While this present surge of diphtheria cases is indeed unprecedented for West Africa, it is really a symptom of larger issues in global health, including insufficient infectious disease surveillance, poor vaccination rates and scarcity of public health resources, suggests Shyaka. He’s not only worried about Guinea’s current diphtheria outbreak but also what other diseases are on the horizon, including meningitis, measles and whooping cough.

“The resurgence of diphtheria is an important indicator that we are far in the red zone of outbreaks — of vaccine-preventable outbreaks.”

Simar Bajaj is an American journalist who has previously written for The AtlanticTIMEThe GuardianWashington Post and more. He is the recipient of the Foreign Press Association award for Science Story of the Year and the National Academies award for Excellence in Science Communications.

Splinter Removal: Tips & Tricks

Getting splinters out can be a tough job sometimes. Not all school nurses prefer to remove splinters but in case you do here are some tips and tricks to hopefully make it a little easier.

First and foremost, if you do not prefer to remove splinters as some do, it is perfectly reasonable to clean the area, cover with a bandaid and let the parent know so they can handle it at home. Many nurses feel that it is outside of their scope of practice to “dig” for a splinter that is not easily removed as it is a more invasive procedure that could be considered “surgery”. If the splinter is sticking out or easily removed then it is ok to grab it with tweezers and remove it or soak it and give it a try but if it is too deep and requires a lot of digging then stop and inform the parent.

If you want to try and get it out here are some tips to make it easier. Before attempting to remove anything make sure that you clean the area well and use clean/sterile packaged equipment, make sure the student does not have an allergy to items used. Always stop if they can’t tolerate the removal attempt.

  1. Splinter-Out (or a cheaper option, a lancet): this is basically a one time use little needle that can help pull the splinter up and out.
  2. Epsom salt soak: mix up some epsom salt and warm water and soak the area for about 10 minutes. Once the splinter swells up enough to remove it you can grab it with tweezers or a Splinter-Out.
  3. Vegetable oil?? soaking the area in vegetable oil for a few minutes might soften the area enough to be able to more easily reach the splinter. have you tried this?
  4. White glue: Not just for ASMR peeling pleasure, if you put some white glue on a splinter and let it dry then peel it off it might pull the splinter out with it!
  5. Honey: put a dab of honey on the splinter and put a bandaid over it and eventually the honey will absorb the moisture bringing the splinter to the surface. Don’t let little kids under 12 months old eat the honey though!
  6. Duct tape: put a little piece of duct tape over the splinter and rub it on really well. When you pull it off it SHOULD pull the splinter with it since it’s super sticky.
  7. Baking soda soak: Mix up a paste with baking soda and water and place it over the splinter. Give it a few hours and hopefully it will cause the splinter to work its way out to where you can grab it.
  8. Hydrogen peroxide: soak the area in hydrogen peroxide and let the bubbles bubble the splinter out.
  9. A 3-5 ml syringe: either a luer lock or a medicine syringe with the tip cut off, place the hole over the splinter and try to suction gently to draw the splinter out.

When all else fails and you can’t get it out without causing excessive pain or bleeding, clean it, cover it and notify parent. They can take the child to the doctor for removal.

https://www.nursingcenter.com/static?pageid=1037067

https://www.quickanddirtytips.com/articles/8-tricks-for-removing-splinters

https://www.aad.org/public/everyday-care/injured-skin/burns/remove-splinters

https://www.cincinnatichildrens.org/health/s/splinters

https://kidshealth.org/en/parents/splinters-sheet.html?ref=search

The Magic of Peppermints

Peppermint

From the Mount Sinai blog:

Mentha x piperita

Peppermint (Mentha piperita), a popular flavoring for gum, toothpaste, and tea, is also used to soothe an upset stomach or to aid digestion. It has a calming and numbing effect, and is often used to treat headaches, skin irritation, nausea, diarrhea, menstrual cramps, flatulence, and anxiety associated with depression. It is also an ingredient in chest rubs used to treat symptoms of the common cold. In test tubes, peppermint kills some types of bacteria, fungi, and viruses, suggesting it may have antibacterial, antifungal, and antiviral properties. Menthol and methyl salicylate, the main ingredients in peppermint, have antispasmodic effects, with calming effects on the gastrointestinal tract. Several studies support the use of peppermint for indigestion and irritable bowel syndrome.

Indigestion

Peppermint calms the muscles of the stomach and improves the flow of bile, which the body uses to digest fats. As a result, food passes through the stomach more quickly. However, if your symptoms of indigestion are related to a condition called gastroesophageal reflux disease or GERD, you should not use peppermint (see “Precautions” section).

Flatulence/Bloating

Peppermint relaxes the muscles that allow painful digestive gas to pass.

Irritable Bowel Syndrome (IBS)

Several studies have shown that enteric-coated peppermint capsules can help treat symptoms of IBS, including pain, bloating, gas, and diarrhea. (Enteric-coated capsules keep peppermint oil from being released in the stomach, which can cause heartburn and indigestion.) However, a few studies have shown no effect. One study examined 57 people with IBS who received either enteric-coated peppermint capsules or placebo twice a day for 4 weeks. Of the people who took peppermint, 75% had a significant reduction of IBS symptoms. Another study comparing enteric-coated peppermint oil capsules to placebo in children with IBS found that after 2 weeks, 75% of those treated had reduced symptoms. Finally, a more recent study conducted in Taiwan found that patients who took an enteric-coated peppermint oil formulation 3 to 4 times daily for 1 month had less abdominal distention, stool frequency, and flatulence than those who took a placebo. Nearly 80% of the patients who took peppermint also had alleviation of abdominal pain.

Itching and Skin Irritation

Peppermint, when applied topically, has a soothing and cooling effect on skin irritation caused by hives, poison ivy, or poison oak.

Tension Headache

One small study suggested that peppermint applied to the forehead and temples helped reduce headache symptoms.

Colds and Flu

Peppermint and its main active agent, menthol, are effective decongestants. Because menthol thins mucus, it is also a good expectorant, meaning it helps loosen phlegm and breaks up coughs. It is soothing and calming for sore throats (pharyngitis) and dry coughs.

Plant Description

Peppermint plants grow to about 2 to 3 feet tall. They bloom from July through August, sprouting tiny purple flowers in whorls and terminal spikes. Dark green, fragrant leaves grow opposite white flowers. Peppermint is native to Europe and Asia, is naturalized to North America, and grows wild in moist, temperate areas. Some varieties are indigenous to South Africa, South America, and Australia.

What’s It Made Of?

The leaves and stems, which contain menthol (a volatile oil), are used medicinally, as a flavoring in food, and in cosmetics (for fragrance).

Available Forms

Peppermint tea is prepared from dried leaves of the plant and is widely available commercially.

Peppermint spirit (tincture) contains 10% peppermint oil and 1% peppermint leaf extract in an alcohol solution. A tincture can be prepared by adding 1 part peppermint oil to 9 parts pure grain alcohol.

Enteric-coated capsules are specially coated to allow the capsule to pass through the stomach and into the intestine (0.2 mL of peppermint oil per capsule).

Creams or ointments (should contain 1% to 16% menthol)

How to Take It

Pediatric

DO NOT give peppermint to an infant or small child. Peppermint oil applied to the face of infants can cause life-threatening breathing problems. In addition, peppermint tea may cause a burning sensation in the mouth. For digestion and upset stomach in older children: 1 to 2 mL peppermint glycerite that is specially formulated for children, per day.

Adult

  • Tea. Steep 1 tsp. (5 grams) dried peppermint leaves in 1 cup boiling water for 10 minutes; strain and cool. Peppermint tea appears to be safe, even in large quantities.
  • Enteric-coated capsules. 1 to 2 capsules (0.2 ml of peppermint oil), 2 to 3 times per day for IBS.
  • Tension headaches. Using a tincture of 10% peppermint oil to 90% ethanol, lightly coat the forehead and allow the tincture to evaporate.
  • Itching and skin irritation. Apply menthol, the active ingredient in peppermint, in a cream or ointment form no more than 3 to 4 times per day.

Precautions

The use of herbs is a time-honored approach to strengthening the body and treating disease. Herbs, however, can trigger side effects and interact with other herbs, supplements, or medications. For these reasons, you should take herbs with care, under the supervision of a health care provider.

DO NOT take peppermint or drink peppermint tea if you have gastroesophageal reflux disease (GERD — a condition where stomach acids back up into the esophagus), or hiatal hernia. Peppermint can relax the sphincter between the stomach and esophagus, allowing stomach acids to flow back into the esophagus. (The sphincter is the muscle that separates the esophagus from the stomach.) By relaxing the sphincter, peppermint may actually worsen the symptoms of heartburn and indigestion.

The amount of peppermint normally found in food is likely to be safe during pregnancy, but not enough is known about the effects of larger supplemental amounts. Some experts even recommend modest amounts of peppermint tea to help alleviate nausea during pregnancy. Speak with your provider before using peppermint or any other herbal products during pregnancy.

Never apply peppermint oil to the face of an infant or small child, as it may cause spasms that inhibit breathing.

Peppermint may make gallstones worse.

Large doses of peppermint oil can be toxic. Pure menthol is poisonous and should never be taken internally. It is important not to confuse oil and tincture preparations.

Menthol or peppermint oil applied to the skin can cause a rash.

Non enteric-coated capsules and peppermint oil can lead to heartburn.

Possible Interactions

Cyclosporine

This drug, which is usually taken to prevent rejection of a transplanted organ, suppresses the immune system. Peppermint oil may slow down the rate at which the body breaks down cyclosporine, meaning more of it stays in your bloodstream. DO NOT take peppermint oil if you take cyclosporine.

Drugs that reduce stomach acid

If you take peppermint capsules at the same time as drugs that lower the amount of stomach acid, the enteric-coated peppermint capsules may dissolve in the stomach instead of the intestines. This could reduce the effects of peppermint. Take peppermint at least 2 hours before or after an acid-reducing drug. Antacids include:

  • Famotidine (Pepcid)
  • Cimetidine (Tagamet)
  • Ranitidine (Zantac)
  • Esomeprazole (Nexium)
  • Lansoprazole (Prevacid)
  • Omeprazole (Prilosec)

Drugs that treat diabetes

Test tube studies suggest peppermint may lower blood sugar, raising the risk of hypoglycemia (low blood sugar).

Medications changed by the liver

Since peppermint works on the liver, it may affect medications that are metabolized by the liver (of which there are many). Speak with your health care provider.

Antihypertensive drugs (blood pressure medications)

Some animal studies suggest that peppermint may lower blood pressure. If you take medications to lower blood pressure, taking peppermint also might make their effect stronger.

Supporting Research

Agarwal V, Lal P, Pruthi V. Effect of plant oils on Candida albicans. J Microbiol Immunol Infect. 2010;43:447-451.

Alam MS, Roy PK, Miah AR, et al. Efficacy of Peppermint oil in diarrhea predominant IBS – a double blind randomized placebo – controlled study. Mymensingh Med J. 2013; 22:27-30.

Blumenthal M, Goldberg A, Brinckmann J. Herbal Medicine: Expanded Commission E Monographs. Newton, MA: Integrative Medicine Communications; 2000:297-303.

Cappello G, Spezzaferro M, Grossi L, Manzoli L, Marzio L. Peppermint oil (Mintoil) in the treatment of irritable bowel syndrome: a prospective double blind placebo-controlled randomized trial. Dig Liver Dis. 2007;39:530-536.

Cash BD, Epstein MS, Shah SM. A novel delivery system of peppermint oil is an effective therapy for irritable bowel syndrome symptoms. Dig Dis Sci. 2016;61(2):560-571.

Ford AC, Talley NJ, Spiegel BM, et al. Effect of fibre, antispasmodics, and peppermint oil in the treatment of irritable bowel syndrome: systematic review and meta-analysis. BMJ. 2008;337:a2313.

Herro E, Jacob SE. Mentha Piperita (peppermint). Dermatitis. 2010;21:327-329.

Imagawa A, Hata H, Nakatsu M, et al. Peppermint oil solution is useful as an antispasmodic drug for esophagogastroduodenoscopy, especially for elderly patients. Dig Dis Sci. 2012;57:2379-2384.

Inamori M, Akiyama T, Akimoto K, et al. Early effects of peppermint oil on gastric emptying: a crossover study using a continuous real-time 13C breath test (BreathID system). J Gastroenterol. 2007;42:539-542.

Kline RM, Kline JJ, Di Palma J, Barbero GJ. Enteric-coated, pH-dependent peppermint oil capsules for the treatment of irritable bowel syndrome in children. J Pediatr. 2001;138:125-128.

Korterink JJ, Rutten JM, Venmans L, Benninga MA, Tabbers MM. Pharacolgic treatment in pediatric functional abdominal pain disorders: a systematic review. J Pediatr. 2015;166(2):424-431.e6.

Lane B, Cannella K, Bowen C, et al. Examination of the effectiveness of peppermint aromatherapy on nausea in women post C-section. J Holist Nurs. 2012;30:90-104.

Madisch A, Holtmann G, Mayr G, Vinson B, Hotz J. Treatment of functional dyspepsia with a herbal preparation. A double-blind, randomized, placebo-controlled, multicenter trial. Digestion. 2004;69:45-52.

Magge S, Lembo A. Complementary and alternative medicine for the irritable bowel syndrome. Gastroenterol Clin North Am. 2011;40(1):245-253.

McKay DL, Blumberg JB. A review of the bioactivity and potential health benefits of peppermint tea (Mentha piperita L). Phytother Res. 2006;20:619-633. Review.

Rakel D. Integrative Medicine. 3rd ed. Philadelphia, PA. Elsevier Saunders; 2012.

Shen YH, Nahas R. Complementary and alternative medicine for treatment of irritable bowel syndrome. Can Fam Physician. 2009;55:143-148.

Yamamoto N, Nakai Y, Sasahira N, et al. Efficacy of peppermint oil as an antispasmodic during endoscopic retrograde cholangiopancreatography. J Gastroenterol Hepatol. 2006;21:1394-1398.

Philadelphia Health Department Update on Measles Outbreak – January 5, 2024

For immediate release: January 05, 2024

Published by: Board of HealthDepartment of Public Health

Contact: Health Department phlpublichealth@phila.gov

PHILADELPHIA—The City continues to respond to the ongoing measles outbreak in Philadelphia.

Current situation

Today, the Health Department reports a total of 5 confirmed and 3 presumed cases of measles associated with this outbreak. Currently, 3 of these cases are hospitalized with measles.

The Health Department is posting regular updates on the City’s website. Check for the latest.

Today’s updates

The Health Department announced that all City Health Centers have the MMR vaccine which can protect you from measles. Any child in Philadelphia can receive free vaccines at City Health Centers. Call Center Operators can be reached at 215-685-2933 to set up an appointment.

Philadelphia has high vaccination rates, with at least 93% of children fully vaccinated against measles by age 6. If you or your child has not yet been vaccinated, call today to get vaccinated.

“If you have not yet been vaccinated against measles or have not vaccinated your children or are 12 months or age or older, reach out to your healthcare provider to do so immediately,” said Health Commissioner Dr. Cheryl Bettigole.

For a limited time, Health Center 3 (555 S 43rd St.), Health Center 4 (4400 Haverford Ave.), and Health Center 5 (1900 N 20th St.) are also offering walk-in MMR vaccinations to any Philadelphia resident, Monday through Thursday 10am -12noon and 1p-3p.

All of these vaccines are free at the City Health Centers. There is no need for an ID, just a piece of mail with your address on it will confirm your residency.

The Health Department reminds Philadelphians that vaccination is the very best way to protect yourself and your children against measles and many other diseases.

The Health Department also released the following timeline to help detail the history of this quickly evolving situation.

  • Early December
    • Patient presented to CHOP with an infection later identified as measles.
    • During that stay, three non-immune patients were exposed and later tested positive for measles.
  • December 23
    • The Health Department was notified that a measles case visited a Jefferson Health building and potentially exposed people there. The City distributed a press release about that potential exposure. To date, no new cases have been reported as a result of that exposure, likely due to intensive contact tracing efforts.
  • January 3
    • The Health Department was notified that a measles case attended a day care facility on December 20 and 21 and exposed children and staff there. At least two additional children who attend that day care have tested positive after visiting various healthcare centers before the Health Department was notified. Both children were hospitalized due to measles infection. The City distributed a press release about the various potential exposure points the following day.
  • January 5
    • Three additional possible measles cases have been identified among the children attending the day care facility. The Health Department continues to work with affected healthcare facilities and the day care to identify people who may have been exposed, checking their immunization status, interviewing to learn where they have been and who they may have exposed since their own exposure, and issuing quarantine recommendations. The City started regular press releases to keep the public informed.

Press notes

The Health Department is coordinating media interviews with Health Commissioner Dr. Cheryl Bettigole. Press are instructed to submit all interview and information requests on the measles outbreak to phlpublichealth@phila.gov.

Press is not being offered access to any of the Health Centers vaccinating clinics at this time in order to preserve anonymity of patients. This may change as the response continues.

For more basic information on measles and vaccines, please see the Health Department’s blog post.

See full press release here: https://www.phila.gov/2024-01-05-health-department-update-on-measles-outbreak-january-5-2024/

DOES SUGAR MAKE KIDS HYPERACTIVE?

COMMON MYTHS

 PRACHI SHAH 

Bowl of American Candy

Image from https://www.2foodtrippers.com/best-american-candy/

Neha Prathivadi

The expression “sugar rush” is one that has been in our vocabularies since our early childhood days. Many parents are concerned about their children’s consumption of candy and other sugary foods, because they fear it will lead to overexcitement and hyperactivity. However, is there actually a link between sugar and hyperactivity in children? Researchers seem to disagree.

The concept of the “sugar rush” originated from the theory that since sugar is a source of energy for our bodies, consuming more sugar should lead to higher energy levels. In reality, our bodies don’t break down all the sugar immediately. Rather, we store it and use small amounts when needed, so we shouldn’t actually show signs of hyperactivity after eating large amounts of sugar. 

An analysis of multiple research studies found that sugar does not impact the behavior or mental performance of children. So, if there is no impact, how do we explain children appearing “hyper” after consuming sugar? The answer may be confirmation bias. Most kids tend to eat sugary foods in fun settings, like birthday parties or family holidays. Our minds may falsely link  the excitement surrounding the event to the sugar. 

Another interesting fact is that sugar blocks the hypothalamic pituitary adrenal (HPA) axis, which is a component of our brain that is associated with stress. Therefore, sugar might lessen stress levels and could actually calm us.

So far, there is no evidence to show a connection between sugar and hyperactivity in children. Nevertheless, it is still important to be aware of what you are consuming in order to maintain a healthy diet and lifestyle. So have fun and enjoy your occasional ice cream, cookie, or candy, but make sure to snack in moderation!

Links:

Assessment Basics: All About Fevers

Fevers are often a misunderstood symptom of illness. Why do we get them and what do we do about them?

A fever is a temporary rise in body temperature. It’s one part of an overall response from the body’s immune system. There are multiple reasons for fevers including infections, viruses, heat exhaustion, sometimes immunizations, and sometimes certain diseases like cancers or inflammatory illness can cause a fever.

When an invader enters the body the immune system begins a cycle of macrophages, white blood cells, monocytes, and lymphocytes to begin a cytokine induction which fights the invader. This is outwardly exhibited by an appreciable rise in body temperature – usually about 100.4 (give or take a tenth of a degree) and above is considered a fever.

Myth: If your perceived “normal” body temperature is always 97.6 and you have a temperature of 99.6 it’s considered a fever. Not entirely true! Yes it is a slight elevation in temperature and can indicate illness but it is not concerning. A temperature of 99.6 – 100.3 can be considered a low grade fever depending on the other symptoms and age of the patient. Body temperature can rise and lower for various reasons such as hot weather, exercising, hormones (if you’re trying to conceive and tracking ovulation, you would find out that when ovulation occurs the basal body temperature increases slightly but that’s for another post), or teething in infants. Don’t worry if a person’s temperature is in the 99’s but they have no other real symptoms.

When do we worry about a fever?

Per Penn Medicine: Contact a provider right away if your child:

  • Is 3 months or younger and has a rectal temperature of 100.4°F (38°C) or higher
  • Is 3 to 12 months old and has a fever of 102.2°F (39°C) or higher
  • Is 2 years or younger and has a fever that lasts longer than 24 to 48 hours
  • Is older and has a fever for longer than 48 to 72 hours
  • Has a fever of 105°F (40.5°C) or higher, unless it comes down readily with treatment and the person is comfortable
  • Has other symptoms that suggest an illness may need to be treated, such as a sore throat, earache, or cough
  • Has had fevers come and go for up to a week or more, even if these fevers are not very high
  • Has a serious medical illness, such as a heart problem, sickle cell anemia, diabetes, or cystic fibrosis
  • Recently had an immunization
  • Has a new rash or bruises
  • Has pain with urination
  • Has a weakened immune system (because of long-term [chronic] steroid therapy, a bone marrow or organ transplant, spleen removal, HIV/AIDS, or cancer treatment)
  • Has recently traveled to another country

Contact your provider right away if you are an adult and you:

  • Have a fever of 105°F (40.5°C) or higher, unless it comes down readily with treatment and you are comfortable
  • Have a fever that stays at or keeps rising above 103°F (39.4°C)
  • Have a fever for longer than 48 to 72 hours
  • Have had fevers come and go for up to a week or more, even if they are not very high
  • Have a serious medical illness, such as a heart problem, sickle cell anemia, diabetes, cystic fibrosis, COPD, or other long-term (chronic) lung problems
  • Have a new rash or bruises
  • Have pain with urination
  • Have a weakened immune system (from chronic steroid therapy, a bone marrow or organ transplant, spleen removal, HIV/AIDS, or cancer treatment)
  • Have recently traveled to another country

Call 911 or the local emergency number if you or your child has a fever and:

  • Is crying and cannot be calmed (children)
  • Cannot be awakened easily or at all
  • Seems confused
  • Cannot walk
  • Has difficulty breathing, even after the nose is cleared
  • Has blue lips, tongue, or nails
  • Has a very bad headache
  • Has a stiff neck
  • Refuses to move an arm or leg (children)
  • Has a seizure

What can we do about a fever?

  • Remove excess clothing, blankets, jackets, hats, socks etc.
  • Try Acetaminophen (Tylenol, Fever-All, Paracetamol). Usually dosed for children at 15 mg/kg, follow the chart on the bottle, or per doctor’s order. Tylenol is given every 4 – 6 hours. For adults taking extra strength Tylenol (1000 mg/2 x 500 mg) it should be taken 6 hours apart, no more than 4000 mg in 24 hours. Acetaminophen can be damaging to the liver and potentially fatal if taken excessively or overdosed. Read about Acetaminophen toxicity here. If the patient is vomiting or unable to take Acetaminophen orally (or through feeding tube) then you have the option of using Fever-All rectal suppositories, sold in most drug stores. That can be reserved for home and healthcare facilities, however, not at school.
  • Try Ibuprofen (Motrin, Advil). Usually dosed for children at 10 mg/kg, follow the chart on the bottle, or doctor’s orders. Ibuprofen should be given every 6-8 hours not exceeding 1200 mg for adults. Ibuprofen can irritate the stomach and lead to vomiting so if the child has a fever accompanied by vomiting, diarrhea, or stomachache then avoid using Ibuprofen. Long term regular use of Ibuprofen can lead to gastrointestinal bleeding, stomach ulcers, and other GI related issues. Read about Ibuprofen toxicity here.
  • For a stubborn fever or more severe pain you can try alternating Motrin and Tylenol. The best way to do this is to take each med 3 hours apart from the other (so each med every 6 hours but taking something every 3). They can be given at the same time but it is more effective for pain relief to alternate. https://www.drugs.com/medical-answers/safe-ibuprofen-with-acetaminophen-2991821/
  • Keep the patient hydrated. Fever can cause them to breathe faster which uses more body fluids and can cause faster dehydration. Children can have sips, spoonfuls, or syringes of diluted full sugar “junk juice” (Juicy Juice or the sugary juices you try to avoid in normal life), caffeine free tea, or Pedialyte. Older children and adults can have water, Gatorade, Pedialyte, or juice.
  • Try a lukewarm bath, NOT a cold bath, an alcohol bath, or an ice bath (this can cause seizures and is not effective in reducing a fever). You can wipe the patient down with a cool cloth or apply cool compresses.
  • Wait it out. Is the patient comfortable with their fever? If they are able to rest and not in pain they can wait it out. A fever does not have to be reduced as it is a self-limiting issue. The main reason to reduce a fever is for the patient’s comfort.
  • Most schools require that a student remain out of school until they are fever free for 24 hours without fever reducing medications. Check your district policy.

Fever Fast facts

  • Fevers are not super dangerous. Understandably, people fear febrile seizures but a high fever does not guarantee a seizure or brain damage. Febrile seizures are associated with the rate in which the temperature rises or falls as opposed to just the number on the thermometer. The seizures can occur when the fever shoots up very fast or goes down too fast. This is why ice baths or “cooling” is something that is only done in the ER or ICU under close medical supervision for very specific circumstances and never at home. Febrile seizures do not equal epilepsy although they do have the possibility of recurrent febrile seizures. They usually go away during childhood.
  • All fevers do not have to be treated. Each circumstance is individual and has many factors. Take into account what other symptoms the patient has, their comfort level, and what the temperature is. A fever is part of the immune system doing it’s job and is there for a reason. Refer to the list above of when to be concerned about a fever. Generally a higher fever will cause some degree of discomfort so you will want to treat it but more mild fevers you can wait and see how it goes.
  • Babies under 3 months with a temp over 100.4 rectally need to be seen in the emergency room. Children that young have an immature immune system and can have serious illness like meningitis or sepsis so they would likely need a series of blood and fluid tests to rule out things like urinary tract infection, meningitis, cancer, sepsis, or even a congenital metabolic disorder. https://www.chop.edu/conditions-diseases/fever-newborn
  • Some people with chronic autoimmune or autoinflammatory disorders can have recurrent fevers. They are not an indication of infection but a manifestation of their chronic condition. https://www.childrenshospital.org/conditions/systemic-autoinflammatory-diseases-saids#:~:text=Recurrent%20fevers%20are%20most%20often,can%20also%20cause%20recurring%20fevers.
  • CRIA Syndrome or Cleavage-resistant RIPK1-induced autoinflammatory syndrome is a recently discovered autoinflammatory disease caused by mutations within the receptor-interacting serine/threonine-protein kinase 1 (RIPK1) gene.The exact prevalence of CRIA syndrome is still undetermined as it has only recently been identified as a disease. Seven people from three separate families in the U.S. have been diagnosed with CRIA syndrome through genetic testing although there may be more we are unaware of yet. The symptoms of CRIA syndrome are that of an autoinflammatory disease characterized by:
    • Persistent episodic unexplained fevers – every 2-4 weeks from birth for 3-5 days
    • Lymphadenopathy – painful swollen lymph nodes – related to the onset of fever
    • Severe abdominal pains, gastrointestinal problems, and diarrhea
    • Headaches
    • Mouth ulcers & tonsillitis
    • Enlarged liver and spleen (hepatomegaly & splenomegaly) – in some patients
  • The best way to check a temperature is orally or rectally. For infants a temperature should be taken rectally unless you are in a setting where that is inappropriate (like daycare) then you can try axillary instead. No touch forehead thermometers are recommended for people 3 months and up also although personally I don’t care for them. They do not recommend otic temperatures on people under 3 months. Over age 4 and able to follow directions can have an oral temperature. You don’t have to add or subtract a degree based on method used, just report what method you used and the temperature you get. https://www.seattlechildrens.org/conditions/a-z/fever-how-to-take-the-temperature/#:~:text=Rectal%20temps%20are%20the%20most,armpit%20are%20the%20least%20accurate.

Things to consider when someone has a fever

What illnesses can cause a fever? The list is very long and we aren’t diagnosing but in a school setting we might consider:

  • Viral: any number of viruses come through our doors from Roseola to RSV to Covid to Influenza.
  • Strep throat
  • A wound infection
  • Pneumonia/walking pneumonia
  • Ear infection
  • Chickenpox/Measles/Mumps (yes, they still exist!)

Do you have any hot tips, fast facts or info about managing fevers that we need to know about? Please comment, email, or join my facebook group and let me know what you think!

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7122269/

https://www.pennmedicine.org/for-patients-and-visitors/patient-information/conditions-treated-a-to-z/fever

https://www.prevention.com/health/a20429676/10-fever-remedies/

https://www.news-medical.net/health/What-is-CRIA-syndrome.aspx#:~:text=The%20symptoms%20of%20CRIA%20syndrome,pains%2C%20gastrointestinal%20problems%2C%20and%20diarrhea

https://www.chop.edu/conditions-diseases/fever-children

From the American Optometric Association: Convergence Insufficiency

January is National Eye Care Month. I recently learned about a condition called Convergence insufficiency that affects the eye muscles but rarely the actual vision of the patient. It is often missed or misdiagnosed as good vision but dyslexia or behavioral problems. Please check out this article from the American Optometric Association.

Convergence insufficiency

Convergence insufficiency (CI) is a common, yet not frequently diagnosed eye coordination problem in which the eyes drift outward when reading or doing close work.

Child has difficulty reading

Causes & risk factors

Convergence insufficiency (CI) is caused by a simple “lack of proper communication” between the nerves and the muscles that control eye movements. The muscles surrounding the eye (there are six) are plenty strong, but the nerves that control these muscles are not sending the proper message to turn inward enough to aim at the target (page or screen).

Symptoms

There are many symptoms listed below. An easy way to explain how it really feels is by comparing your eyes when reading to driving along the interstate. When driving is normal, your car is usually in one lane but there are two lanes that can be used, thus giving a feeling of comfort. When you enter a construction zone, squeezed down to one lane with concrete barriers on each side of you, there is still plenty of room for your car, but not as much as with two lanes. The result is you most likely will slow down, hold the wheel tighter, stiffen your shoulders, and overall feel more stressed.

Your eyes have a similar comfort zone called the fusional range. Your fusional range is how far inward and how far outward your eyes can move and still see single and comfortable. If that range is narrow, just like the construction zone, you will slow down and feel more stressed when you are reading because there is one thing your brain hates and that is seeing double. In order to not see double, eyes start working very hard to maintain single vision.

This can lead to a multitude of symptoms including eyestrain (especially with or after reading), plus:

  • Headaches.
  • Blurred vision.
  • Double vision.
  • Inability to concentrate.
  • Short attention span.
  • Frequent loss of place.
  • Squinting, rubbing, closing, or covering an eye.
  • Sleepiness during the activity.
  • Trouble remembering what was read.
  • Words appear to move, jump, swim, or float.
  • Problems with motion sickness and/or vertigo.

Diagnosis

CI can almost be diagnosed by listening to the patient describe their symptoms. If these symptoms (all or some) are noted, extra testing can be performed to diagnose or rule out CI. It is important to note that most routine eye exams will not include specific testing for CI, so it is important that the patient or parent explains in detail the symptoms he/she is having. That will signal the doctor to add extra testing to see how well the eyes work together.

Treatment

Treatment can be active or passive. Active treatment involves fairly intense eye exercises that retrain the nerves to aim the eyes properly and increase the fusional range. The most successful treatment involves home plus office therapy. The least successful involves an older form of treatment called “pencil push-ups”. Pencil push-ups can help but only when incorporated into a complete therapy program. Active treatment can last up to 90 days or more and typically the results are permanent. Passive treatment is more like a crutch that works only when in place. Prisms can be incorporated into reading glasses that redirect light entering the eyes. Think of it as the lenses doing the work the nerves don’t know how to do.

Prevention

In the case of CI, treatment is part of the prevention. This is because if the condition is not properly treated, it can progress into a much more serious condition called intermittent exotropia. This is the brain’s answer to coping with double vision and the stress of eyes not working as a team. The eyes may drift further apart and simply begin working independently rather than as a team. This can lead to a whole host of new problems. Our brain is wired for two eyes to work together and when this doesn’t happen, the problems begin to go beyond discomfort while reading. The use of one eye is suppressed.

Suppression of vision in one eye causes loss of binocular (two-eyed) vision and depth perception. Poor binocular vision can have a negative impact on many areas of life, such as coordination, sports, the judgment of distances, eye contact, motion sickness, etc. Consequently, a person with convergence insufficiency who is suppressing one eye can show some or all of the following symptoms:

  • Trouble catching balls and other objects thrown through the air.
  • Avoidance of tasks that require depth perception (games involving smaller balls traveling through the air, handicrafts, and/or hand-eye coordination, etc.)
  • Frequent mishaps due to misjudgment of physical distances (particularly within twenty feet of the person’s body), such as:
    • Trips and stumbles on uneven surfaces, stairs, and curbs, etc.
    • Frequent spilling or knocking over objects.
    • Bumping into doors, furniture, and other stationary objects.
    • Sports and/or car parking accidents.
  • Avoidance of eye contact.
  • Poor posture while doing activities requiring near vision.
  • One shoulder is noticeably higher.
  • Frequent head tilt.
  • Problems with motion sickness and/or vertigo.

In summary, CI is a common but frequently missed diagnosis (one can have uncorrected vision in each eye of 20/20 vision and still have CI so screenings at work and school will totally miss it). CI is also very treatable if diagnosed. However, treatment is patient intensive. If the patient doesn’t do the therapy, there will be no improvement.

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